Concepedia

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

Maria Digiacomo, Ziwei Chen, Shengnan Wang, Annalina Lapucci, Marco Macchia, Xiaohong Yang, Jiaqi Chu, Yifan Han, Rongbiao Pi, Simona Rapposelli

Bioorganic & Medicinal Chemistry Letters · 2015 · 69 citations · 16 references

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16

Treatment of Alzheimer's disease; current status and new perspectives

Elio Scarpini, Philip Schelterns, Howard Feldman · The Lancet Neurology · 2003 · 725 citations

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Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

María Isabel Fernández‐Bachiller, Concepción Pérez, Gema C. González-Muñoz et al. · Journal of Medicinal Chemistry · 2010 · 268 citations · Full text

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Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

Paul R. Carlier, Yifan Han, Ella S.‐H. Chow et al. · Bioorganic & Medicinal Chemistry · 1999 · 158 citations · Full text

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Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors

Chen Yao, Lei Fang, Mei Liu et al. · Journal of Medicinal Chemistry · 2012 · 134 citations · Full text

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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Michel Maillard, Roy K. Hom, Timothy E. Benson et al. · Journal of Medicinal Chemistry · 2007 · 111 citations · Full text

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