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Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes

Steen Larsen, Nis Stride, Martin Hey‐Mogensen, Christina Hansen, Jesper L. Andersen, Sten Madsbad, Dorte Worm, Jørn Wulff Helge, Flemming Dela

Diabetologia · 2011 · 70 citations · 32 references

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References

32

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Vamsi K. Mootha, Cecilia M. Lindgren, Karl‐Fredrik Eriksson et al. · Nature Genetics · 2003 · 10.6K citations

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Calculation of substrate oxidation rates in vivo from gaseous exchange

Keith N. Frayn · Journal of Applied Physiology · 1983 · 2.4K citations

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Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

David E. Kelley, Jing He, Elizabeth V. Menshikova et al. · Diabetes · 2002 · 2.3K citations · Full text

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

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Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Timothy R. Koves, John R. Ussher, Robert C. Noland et al. · Cell Metabolism · 2008 · 2K citations · Full text

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