Concepedia

Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors

Tomoharu Tsukada, Mizuki Takahashi, Toshiyasu Takemoto, Osamu Kanno, Takahiro Yamane, Sayako Kawamura, Takahide Nishi

Bioorganic & Medicinal Chemistry Letters · 2009 · 32 citations · 16 references

DOIFull text

Open access

Concepts

References

16

Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate.

S.J. Pilkis, M. Raafat El‐Maghrabi, J Pilkis et al. · Journal of Biological Chemistry · 1981 · 236 citations · Full text

, , +16

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes

Mark D. Erion, Paul D. van Poelje, Qun Dang et al. · Proceedings of the National Academy of Sciences · 2005 · 162 citations

, , +17

Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

Qun Dang, Srinivas Rao Kasibhatla, K. Raja Reddy et al. · Journal of the American Chemical Society · 2007 · 97 citations

, , +17

Toward a Mechanism for the Allosteric Transition of Pig Kidney Fructose-1,6-Bisphosphatase

Yiping Zhang, J Y Liang, Shenghua Huang et al. · Journal of Molecular Biology · 1994 · 94 citations

, , +13

Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity

Mark D. Erion, Qun Dang, M. Rami Reddy et al. · Journal of the American Chemical Society · 2007 · 91 citations

, , +17