2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

Abstract

2OG and other 2-monoacylglycerols formed during fat digestion can activate GPR119 and cause incretin release from the human intestine. This mechanism is likely to contribute to the known stimulatory effect of dietary fat on incretin secretion, and it indicates that GPR119 is a fat sensor.