Sensitivity and Specificity of P53 Protein Detection by Immunohistochemistry in Patients with Urothelial Bladder Carcinoma

Abstract

There is a moderate correlation between p53 mutations and P53 protein overexpression, with this stronger in high-grade, infiltrating tumors, in exon 8 mutations, and when the mutation induces relevant changes in the protein structure. Although IHC is useful in routine clinical practice, the classic prognostic factors should still be considered the most important in the follow-up of these patients.