Concepedia

Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities

Guangan He, Zahid H. Siddik, Zai-Feng Huang, Ruoning Wang, John M. Koomen, Ryûji Kobayashi, Abdul R. Khokhar, Jian Kuang

Oncogene · 2005 · 268 citations · 51 references

DOI

Concepts

References

51

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

J. Wade Harper · Cell · 1993 · 5.7K citations

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Manuel Serrano, Gregory J. Hannon, David Beach · Nature · 1993 · 3.7K citations

, , +17

p21 is a universal inhibitor of cyclin kinases

Yue Xiong, Gregory J. Hannon, Hui Zhang et al. · Nature · 1993 · 3.4K citations

, , +14

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Kornélia Polyák, Mong-Hong Lee, Hediye Erdjument‐Bromage et al. · Cell · 1994 · 2.1K citations

, , +15

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Pumin Zhang, J. Wade Harper, Stephen J. Elledge et al. · Cell · 1995 · 2.1K citations · Full text

, , +11