Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450

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Medicine, Biochemistry, Pharmacology +11

IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT

Hiroshi Iwata, Yasuhiro Tezuka, Shigetoshi Kadota et al. · Drug Metabolism and Disposition · 2004 · 154 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4

William K. Chan, Anthony B. Delucchi · Life Sciences · 2000 · 151 citations

Medicine, Biochemistry, Pharmacology +14

Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2.

Thomas K. H. Chang, Jie Chen, W B Lee · PubMed · 2001 · 137 citations

Medicine, Pharmacology, Biochemical Toxicology +16