Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

Oscar B. Goodman, Jason G. Krupnick, Francesca Santini et al. · Nature · 1996 · 1.4K citations

Molecular Pharmacology, Molecular Physiology, Signal Transduction +13

Phosphatidylinositol 3-Kinase Encoded by Yeast <i>VPS</i> 34 Gene Essential for Protein Sorting

Peter Schu, Kaoru Takegawa, Michael Fry et al. · Science · 1993 · 919 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

Hiroshi Yano, S. Nakanishi, Koutarou D. Kimura et al. · Journal of Biological Chemistry · 1993 · 737 citations · Full text

Immunology, Cellular Pharmacology, Experimental Pharmacology +19

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

Marco Falasca · The EMBO Journal · 1998 · 561 citations · Full text

Proteinlipid Interaction, Signal Transduction, Cell Regulation +11

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

Stephen K. Dove, Frank T. Cooke, Michael R. Douglas et al. · Nature · 1997 · 465 citations

Signal Transduction, Osmotic Stress, Biochemistry +7