Concepedia

NPM1 Deletion Is Associated with Gross Chromosomal Rearrangements in Leukemia

Roberta La Starza, Caterina Matteucci, Paolo Gorello, Lucia Brandimarte, Valentina Pierini, Barbara Crescenzi, Valeria Nofrini, Roberto Rosati, Enrico Gottardi, Giuseppe Saglio,

PLoS ONE · 2010 · 22 citations · 14 references

DOIFull text

Open access

Abstract

NPM1/5q35 deletion is a consistent event in MDS/AML with a 5q-/-5 in complex karyotypes. NPM1 deletion and NPM1 exon 12 mutations appear to be mutually exclusive and are associated with two distinct cytogenetic subsets of MDS and AML.

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