Relation between<i>CYP2D6</i>Genotype, Personality, Neurocognition and Overall Psychopathology in Healthy Volunteers

Abstract

In the studied population of healthy volunteers, PMs versus EMs showed lower vulnerability to psychopathology and greater impulsivity. Moreover, differences in neurocognition were found. The cross-study reproducibility of the relationship between CYP2D6 and personality may be difficult due to the influence of psychopathology among other factors. The personality and cognitive factors found in PMs appear compatible with a low serotonin/high dopamine balance.