The clinical efficacy of poly(ethylene glycol)-modified proteins

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

Abraham Abuchowski, Judy McCoy, Nicholas C. Palczuk et al. · Journal of Biological Chemistry · 1977 · 1.3K citations · Full text

Life Sciences, Biochemistry, Immunology +14

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

Michael S. Hershfield, Rebecca H. Buckley, Michael Greenberg et al. · New England Journal of Medicine · 1987 · 447 citations

Life Sciences, Biochemistry, Pharmacology +16

Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates.

Abraham Abuchowski, Kazo Gm, Verhoest Cr et al. · PubMed · 1984 · 251 citations

Medicine, Oncology, Pharmacology +13

Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase

Yael Levy, Michael S. Hershfield, Cristina Fernández‐Mejía et al. · The Journal of Pediatrics · 1988 · 214 citations

Life Sciences, Infectious Diseases, Pharmacotherapy +6

Oxygen Radical Dependent Lung Damage following Thermal Injury of Rat Skin

Gerd O. Till, Charles Beauchamp, DAVID MENAPACE et al. · The Journal of Trauma: Injury, Infection, and Critical Care · 1983 · 183 citations

Medicine, Immunology, Pathobiology +17