<scp>LRP</scp> 4 antibodies in serum and <scp>CSF</scp> from amyotrophic lateral sclerosis patients

Abstract

We infer that LRP4 autoantibodies are involved in patients with neurological manifestations affecting LRP4-containing tissues and are found more frequently in ALS patients than MG patients. LRP4 antibodies may have a direct pathogenic activity in ALS by participating in the denervation process.