Concepedia

Glycine Residues Appear to Be Evolutionarily Conserved for Their Ability to Inhibit Aggregation

Claudia Parrini, Niccolò Taddei, Matteo Ramazzotti, Donatella Degl’Innocenti, Giampietro Ramponi, Christopher M. Dobson, Fabrizio Chiti

Structure · 2005 · 98 citations · 30 references

DOIFull text

Open access

Concepts

References

30

Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl .alpha.-chymotrypsin using different denaturants

Marcelo M. Santoro, D. Wayne Bolen · Biochemistry · 1988 · 1.6K citations

, , +7

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

Camilla Nilsberth, Anita Westlind‐Danielsson, Christopher B. Eckman et al. · Nature Neuroscience · 2001 · 1.2K citations

, , +14

Rationalization of the effects of mutations on peptide andprotein aggregation rates

Fabrizio Chiti, Massimo Stefani, Niccolò Taddei et al. · Nature · 2003 · 1.1K citations

, , +12

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

David R. Booth, Margaret Sunde, Vittorio Bellotti et al. · Nature · 1997 · 1K citations

, , +14

Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation

Jane S. Richardson, David Richardson · Proceedings of the National Academy of Sciences · 2002 · 773 citations · Full text

, , +15