Concepedia

Dolastatins. 26. Synthesis and Stereochemistry of Dolastatin 11<sup>1</sup><sup>a</sup>

Robert B. Bates, Kennard G. Brusoe, Jennifer Burns, Sriyani Caldera, Cui Wei, Sanjeev Gangwar, Michelle R. Gramme, Kelly J. McClure, Gregory P. Rouen, Heiko Schadow,

Journal of the American Chemical Society · 1997 · 43 citations · 9 references

DOI

Concepts

Abstract

The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.

References

9

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride (1) as a coupling reagent for N-alkyl amino acids

Roger D. Tung, Daniel H. Rich · Journal of the American Chemical Society · 1985 · 118 citations

, , +17

Structure of majusculamide C, a cyclic depsipeptide from Lyngbya majuscula

Daniel C. Carter, Richard E. Moore, Jon S. Mynderse et al. · The Journal of Organic Chemistry · 1984 · 116 citations

, , +18

Efficient total synthesis of didemnins A and B

Yasumasa Hamada, Yutaka Kondo, Makoto Shibata et al. · Journal of the American Chemical Society · 1989 · 90 citations

, , +12

Isolation and Structure of the Cell Growth Inhibitory Depsipeptides Dolastatins 11 and 12

George R. Pettit, Yoshiaki Kamano, Haruhisa Kizu et al. · Heterocycles · 1989 · 79 citations · Full text

, , +11

Synthesis of cyclic peptides via efficient new coupling reagents

Angelika Ehrlich, Sven Rothemund, M. Brudel et al. · Tetrahedron Letters · 1993 · 74 citations

, , +3