Isolation and Structure of the Cell Growth Inhibitory Depsipeptides Dolastatins 11 and 12

Abstract

Two antmeoplastic cyclic depsipeplides destgnated dolastatin 11 (I) and dolastatm 12(2) were isolated from the Indian Ocean sea hare Dolahello nwiculonu.Dolastatins I I and I2 inhibated growth of the PS leukemia wllh EDSO 2.7 x 10-3 and 7.5 x p9/mL respectively.Detailed structural studies employing 400 MHz lH,tH-COSY, 1H.'3C-COSY, NOE, and