A Convenient Synthesis of Platelet-Activating Factors and Their Analogues from Chiral Epichlorohydrin

Abstract

Abstract Two platelet activating factors (PAF) were conveniently prepared from optically active epichlorohydrin via 5 steps in 15–16% total yield. Four analogues containing oleoyl, propyl, p-trifluoromethylphenoxy, and N,N-dimethyldithiocarbamoyl groups were also prepared.