Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi, +17

Nature Medicine

ObesityBiochemistryAmp-activated Protein KinaseFatty-acid OxidationPhysiology +7

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

Zhidan Wu, Pere Puigserver, Chen‐Yu Zhang, +7

Cell

Mitochondrial BiogenesisBiochemistryMitochondrial FunctionNatural SciencesMolecular Biology +8

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari, +3

Science

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Jiandie D. Lin, Paul T. Tarr, Chen-Yu Zhang, +9

Nature

Transcriptional RegulationMuscle PhysiologyMolecular PhysiologyNeuromuscular PhysiologyMuscle Function +12

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

David E. Kelley, Jing He, Elizabeth V. Menshikova, +1

Diabetes

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Kitt Falk Petersen, Sylvie Dufour, Douglas E. Befroy, +2

New England Journal of Medicine

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

Kitt Falk Petersen, Douglas E. Befroy, Sylvie Dufour, +6

Science

AgingMetabolic DisorderMitochondrial DysfunctionInsulin SignalingMetabolic Syndrome +15

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

E. Dale Abel, Odile D. Peroni, Jason K. Kim, +6

Nature

ObesityMetabolic SyndromeBiochemistryLiver PhysiologyPhysiology +8

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

John J. Lehman, Philip M. Barger, Attila Kovács, +3

Journal of Clinical Investigation

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Jiandie D. Lin, Pei-Hsuan Wu, Paul T. Tarr, +20

Cell

Energy HomeostasisEnergy MetabolismHealth SciencesBiochemistryCns-linked Hyperactivity +10