7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: Synthesis and in vitro biological evaluation as potential antitumor agents

Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.

Linus L. Shen, André G. Pernet · Proceedings of the National Academy of Sciences · 1985 · 372 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

Influence on Mitochondria and Cytotoxicity of Different Antibiotics Administered in High Concentrations on Primary Human Osteoblasts and Cell Lines

N. Duewelhenke, Oleg Krut, Peer Eysel · Antimicrobial Agents and Chemotherapy · 2006 · 212 citations · Full text

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Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts

Peter Hüssy, Burkhard Tümmler, U. Schomburg · Antimicrobial Agents and Chemotherapy · 1986 · 186 citations · Full text

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Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells

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Medicine, Oncology, Pharmacology +13

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA

Linus L. Shen, John L. Baranowski, André G. Pernet · Biochemistry · 1989 · 183 citations

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