Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans

A pharmacokinetic analysis program (multi) for microcomputer.

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Pharmacy, Pharmacokinetics, Pharmacology +12

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans

Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 442 citations

Pharmacy, Biochemistry, Pharmacology +16

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

Yoshio Kameyama, Keiko Yamashita, Kaoru Kobayashi et al. · Pharmacogenetics and Genomics · 2005 · 378 citations

Life Sciences, Biochemistry, Molecular Biology +9

Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

Satoshi Kitamura, Kazuya Maeda, Yi Wang et al. · Drug Metabolism and Disposition · 2008 · 355 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS

Takashi Nozawa, Hironobu Minami, Shigeki Sugiura et al. · Drug Metabolism and Disposition · 2004 · 315 citations

Pharmacy, Pharmacokinetics, Pharmacology +17