Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge

Publication | Open Access

DOI Full Paper Access

Citations

References

2008

Year

Qingzhong Hu, Matthias Negri, Kerstin Jahn‐Hoffmann, Yan Zhuang, Süreyya Ölgen, Marc Bartels, Ursula Müller‐Vieira, Thomas Lauterbach, Rolf W. Hartmann

Bioorganic & Medicinal Chemistry

Methylene ImidazoleMedicinal ChemistryBiochemistryMethylene BridgeBiocatalysisNatural SciencesMedicineEnzyme CatalysisCore RigidificationPharmacologyMolecular ModelingPharmaceutical ChemistryDrug Discovery