Primate Cytomegaloviruses Encode and Express an IL-10-like Protein

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

Henrik Nielsen, Jacob Engelbrecht, Søren Brunak et al. · Protein Engineering Design and Selection · 1997 · 5.4K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

Michael A. Frohman, Michael Dush, Gail R. Martin · Proceedings of the National Academy of Sciences · 1988 · 4.6K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

David Fiorentino, M W Bond, Timothy R. Mosmann · The Journal of Experimental Medicine · 1989 · 2.7K citations

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Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

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Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

F Rousset, Elisabeth Garcia, Thierry Defrance et al. · Proceedings of the National Academy of Sciences · 1992 · 1.3K citations

Life Sciences, Cell Biology, Immunology +17