Concepedia

MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice

Yang Pan, Jia, Zhang, Zhang, Zhang, Li, Lunan Wang

International Journal of Nanomedicine · 2012 · 102 citations · 26 references

DOIFull text

Open access

Abstract

Restoring the loss of miR-146a was effective in eliminating the production of autoantibodies and ameliorating SLE progression in lupus-prone mice. Thus, the induction of dysregulated miRNAs by an MS2 VLP-based delivery system may lead to novel therapies.

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