<scp><i>STAT6</i></scp> polymorphisms are associated with neonatal regulatory <scp>T</scp> cells and cytokines and atopic diseases at 3 years

Abstract

Two STAT6 polymorphisms were associated with altered immune responses already at birth. STAT6 rs324011 was associated with lower neonatal Treg and increased Th1 response. Those neonates had a lower risk of atopic dermatitis and obstructive bronchitis until 3 years. Our data suggest a role for STAT6 polymorphisms in early immune regulation and implications on early atopic disease development.