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Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

Junqing Guo, Andrew J. Watson, James Kempson, Marianne Carlsen, Joseph Barbosa, Karen Stebbins, Deborah Lee, John H. Dodd, Steven G. Nadler, Murray McKinnon,

Bioorganic & Medicinal Chemistry Letters · 2009 · 21 citations · 11 references

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11

Comprehensive medicinal chemistry II

J. B. Taylor · 2007 · 466 citations

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CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

Linsong Li, Cassian Yee, Joseph A. Beavo · Science · 1999 · 256 citations

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Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

Susan J. Smith, L B Cieslinski, Robert Newton et al. · Molecular Pharmacology · 2004 · 164 citations

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Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells

Susan J. Smith, Steven Brookes-Fazakerley, Louise Donnelly et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2003 · 121 citations

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Phosphodiesterase 7A-Deficient Mice Have Functional T Cells

Guchen Yang, Kim W. McIntyre, Robert M. Townsend et al. · The Journal of Immunology · 2003 · 97 citations · Full text

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