A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

Life Sciences, Cancer Biology, Molecular Biology +13

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

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Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

Victoria M. Richon, Todd W. Sandhoff, Richard A. Rifkind et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations · Full text

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Psammaplins from the Sponge <i>Pseudoceratina </i><i>p</i><i>urpurea:</i> Inhibition of Both Histone Deacetylase and DNA Methyltransferase

Ivette C. Piña, Jeffrey T. Gautschi, Gui-Yang-Sheng Wang et al. · The Journal of Organic Chemistry · 2003 · 310 citations

Life Sciences, Biochemistry, Marine Biology +17

Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9

Vesco Mutskov, Gary Felsenfeld · The EMBO Journal · 2003 · 301 citations · Full text

Life Sciences, Genetics, Molecular Biology +16