IL-4 Deficiency Prevents Eosinophilic Rejection and Uncovers a Role for Neutrophils in the Rejection of MHC Class II Disparate Skin Grafts

Abstract

Eosinophil infiltrates, typical of MHC class II disparate acute skin graft rejection, are critically dependent on the availability of IL-4. IL-4 mice reject MHC class II disparate skin grafts by a pathway of rejection where neutrophils play a direct causal role.