Concepedia

Bcl-2 and Bax function independently to regulate cell death

C. Michael Knudson, Stanley J. Korsmeyer

Nature Genetics · 1997 · 396 citations · 37 references

DOI

Concepts

References

37

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

, , +12

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

, , +13

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

David L. Vaux, Suzanne Cory, Jerry M. Adams · Nature · 1988 · 3.2K citations

, , +12

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

Elizabeth Yang, Jiping Zha, Jennifer Jockel et al. · Cell · 1995 · 2.1K citations · Full text

, , +7

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Deborah J. Veis, Christine M. Sorenson, John R. Shutter et al. · Cell · 1993 · 1.6K citations

, , +8