Isolation and structure of the cancer cell growth inhibitor dictyostatin 1

Abstract

Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated (3.4 × 10–7% yield) from a Republic of Maldives marine sponge in the genus Spongia and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.