Proceedings of the National Academy of Sciences · 2004 · 59 citations · 26 references
Life SciencesDevelopmental BiologyNeuroscienceCraniofacial DevelopmentDevelopmental NeuroscienceEmbryogenesisDevelopmental Cell SignalingNeural DevelopmentNeural PatterningNeural Stem Cell BiologyNeural Stem CellsWnt SignalingBeta-catenin RegulationCanonical Wnt PathwayFacial BonesNeural Cell Fate SpecificationNeural Fate SpecificationWnt In DevelopmentWnt In EmbryogenesisWnt In Morphogenesis
Inhibitor of beta-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between beta-catenin and T cell factor. Here we show that ICAT(-/-) embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT(-/-) embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling.
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Wnt proteins are lipid-modified and can act as stem cell growth factors
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