Retinoic Acid Isomers Applied to Human Skin in Vivo Each Induce a 4-Hydroxylase That Inactivates Only Trans Retinoic Acid

Application of Retinol to Human Skin In Vivo Induces Epidermal Hyperplasia and Cellular Retinoid Binding Proteins Characteristic of Retinoic Acid but Without Measurable Retinoic Acid Levels or Irritation

Sewon Kang, Gary J. Fisher, Subhash C. Datta et al. · Journal of Investigative Dermatology · 1995 · 333 citations · Full text

Medicine, Dermatology, Dermatopathology +6

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

Maria A. Leo, Jerome M. Lasker, Judy L. Raucy et al. · Archives of Biochemistry and Biophysics · 1989 · 180 citations

Life Sciences, Biochemistry, Pharmacology +12

Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal.

Elizabeth S. Roberts, Alfin D. N. Vaz, Minor J. Coon · Molecular Pharmacology · 1992 · 164 citations

Life Sciences, Biochemistry, Cellular Metabolism +12

Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro.

Eric J. Duell, Anders Åström, C.E.M. Griffiths et al. · Journal of Clinical Investigation · 1992 · 124 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Effectiveness and pharmacokinetics of low-dose all-trans retinoic acid (25 mg/m2) in acute promyelocytic leukemia

Sylvie Castaigné, Philippe Lefèbvre, Christine Chomienne et al. · Blood · 1993 · 104 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +13