A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.8K citations

Essential Function, Viral Replication, Molecular Virology +10

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.4K citations · Full text

Inflammation, Host Response, Molecular Immunology +9

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Rashu B. Seth, Lijun Sun, Chee-Kwee Ea et al. · Cell · 2005 · 3.2K citations · Full text

Signal Transduction, Mitochondrial Function, Mitochondrial Dynamic +6

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, L. Kerrie et al. · Nature Immunology · 2003 · 2.7K citations

Signal Transduction, Signaling Pathway, Cell Regulation +9

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Taro Kawai, Ken Takahashi, Shintaro Sato et al. · Nature Immunology · 2005 · 2.5K citations

Mda5-mediated Type, Signal Transduction, Natural Sciences +6