The effect of ABCG2 V12M, Q141K and Q126X, known functional variants<i>in vitro</i>, on the disposition of lamivudine

Abstract

Lamivudine appeared to be a substrate of ABCG2 in vitro, but the disposition of lamivudine was not significantly influenced by known in vitro functional variants of ABCG2, Q141K, V12M and Q126X in healthy subjects.