Concepedia

The effect of ABCG2 V12M, Q141K and Q126X, known functional variants<i>in vitro</i>, on the disposition of lamivudine

Ho‐Sook Kim, Yu Eun Sunwoo, Ji Young Ryu, Ho‐Jin Kang, Hye‐Eun Jung, Im‐Sook Song, Eun‐Young Kim, J.-C. Shim, Ji‐Hong Shon, Jae‐Gook Shin

British Journal of Clinical Pharmacology · 2007 · 53 citations · 30 references

DOIFull text

Open access

Abstract

Lamivudine appeared to be a substrate of ABCG2 in vitro, but the disposition of lamivudine was not significantly influenced by known in vitro functional variants of ABCG2, Q141K, V12M and Q126X in healthy subjects.

References

30

A multidrug resistance transporter from human MCF-7 breast cancer cells

L. Austin Doyle, Weidong Yang, Lynne V. Abruzzo et al. · Proceedings of the National Academy of Sciences · 1998 · 2.3K citations · Full text

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

R Allikmets, Lynn M. Schriml, Amy Hutchinson et al. · PubMed · 1998 · 798 citations

, , +16

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

John D. Schuetz, Michele Connelly, Daxi Sun et al. · Nature Medicine · 1999 · 577 citations

, , +11

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

Jan Wijnholds, Carla A.A.M. Mol, Liesbeth van Deemter et al. · Proceedings of the National Academy of Sciences · 2000 · 472 citations · Full text

, , +15

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

Yasuo Imai, Minoru Nakane, Kumie Kage et al. · PubMed · 2002 · 441 citations

, , +18