The Journal of Organic Chemistry · 2008 · 31 citations · 34 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistrySynthetic Medicinal ChemistryConjugation ReactionsAsymmetric Heterocycle SynthesisConjugate AdditionEnantioselective SynthesisLactam MacrocyclesLactam SynthesisPiperidine ChemistryPiperidine Synthesis
A synthetic route to enantiopure cis-2,4-disubstituted and 2,4-bridged piperidines is reported, the key step being a stereoselective conjugate addition of an organocuprate to a phenylglycinol-derived unsaturated lactam bearing a substituent at the 8a-position.
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Maxime G. P. Buffat · Tetrahedron · 2004 · 546 citations
Recent advances in the synthesis of piperidones and piperidines
Philip M. Weintraub, Jeffrey S. Sabol, John M. Kane et al. · Tetrahedron · 2003 · 458 citations
Stereoselective Synthesis of Piperidines
Sabine Laschat, Tim Dickner · Synthesis · 2000 · 377 citations