Concepedia

The Colitis-Associated Transcriptional Profile of Commensal Bacteroides thetaiotaomicron Enhances Adaptive Immune Responses to a Bacterial Antigen

Jonathan J. Hansen, Yong Huang, Daniel A. Peterson, Laura E. Goeser, Ting-Jia Fan, Eugene B. Chang, R. Balfour Sartor

PLoS ONE · 2012 · 43 citations · 40 references

DOIFull text

Open access

Abstract

B. theta induces colitis in HLA-B27 Tg rats, which is associated with regulation of bacterial genes in metabolic and nutrient binding pathways that may affect host immune responses. These studies of the host-microbial dialogue may lead to the identification of novel microbial targets for IBD therapies.

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