Chemical and Pharmaceutical Bulletin · 1989 · 24 citations · 0 references
Bioorganic ChemistryPharmacotherapyChemical BiologyStreptomyces Matensis A-6621Pharmaceutical ChemistryThrombosisMedicinal ChemistryBiosynthesisPlatelet ConcentratesHematologyCultured BrothPlatelet AntagonistPlatelet BiologyBiochemistryChemical MethodsAntimicrobial CompoundPharmacologyPlatelet ActivationPlatelet Aggregation InhibitorsBlood PlateletNatural SciencesMedicineDrug Discovery
From a cultured broth of Streptomyces matensis A-6621, we isolated three new platelet aggregation inhibitors designated as PI-080, PI-085 and PI-087. The structures of these compounds were established by spectral and chemical methods.