BRAFV600E detection in melanoma is highly improved by COLD-PCR

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

Somatic Variant, Braf Gene, Genetics +5

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith et al. · Nature · 2007 · 3.1K citations · Full text

Somatic Mutation, Somatic Variant, Genetics +2

B-RAF is a therapeutic target in melanoma

Maria Karasarides, Antonio Chiloeches, Robert Hayward et al. · Oncogene · 2004 · 432 citations

Tumor Biology, Medicine, Melanoma +5

Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing

Jin Li, Lilin Wang, Harvey J. Mamon et al. · Nature Medicine · 2008 · 371 citations

Genetic Analysis, Dna Sequencing, Genetic Testing +10

PLX4032, a selective BRAF ^V600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF ^WT melanoma cells

Ruth Halaban, Wengeng Zhang, Antonella Bacchiocchi et al. · Pigment Cell & Melanoma Research · 2010 · 321 citations · Full text

Cancer Biology, Melanoma Cells, Tumor Biology +18