Concepedia

An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure–affinity relationship for butyrophenones

Ivan T. Lee, Shiuhwei Chen, John A. Schetz

European Journal of Pharmacology · 2007 · 32 citations · 77 references

Open access

Concepts

Molecular PharmacologyBiochemistryMedicineNatural SciencesMechanism Of ActionMolecular BiologyReceptor (Biochemistry)Distinct Structure–affinity RelationshipUnambiguous AssayDopaminePharmacologyDopamine Research

References

77

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

Cent Inhibition, Inhibitory Activity, Biochemistry +8

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

Markus Hanner, Fabian F. Moebius, Astrid Flandorfer et al. · Proceedings of the National Academy of Sciences · 1996 · 905 citations

Drug Target, Sigma1-binding Site, Molecular Biology +17

A proposal for the classification of sigma binding sites

Rémi Quirion, Wayne D. Bowen, Yossef Itzhak et al. · Trends in Pharmacological Sciences · 1992 · 752 citations

Engineering, Data Science, Scientific Data Management +5

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

Tsung‐Ping Su, Edythe D. London, Jerome H. Jaffe · Science · 1988 · 541 citations

Immune Systems, Immune Regulation, Immunology +17