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TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy

DOIFull Paper Access

133

Citations

41

References

2010

Year

Swarnali Acharyya, Sudarshana M. Sharma, Alfred S.L. Cheng, Katherine J. Ladner, Wei He, William O. Kline, Huating Wang, Michael C. Ostrowski, Tim H.M. Huang, Denis C. Guttridge
PLoS ONE

Abstract

We propose that in dystrophic muscles, elevated levels of TNFalpha and NF-kappaB inhibit the regenerative potential of satellite cells via epigenetic silencing of the Notch-1 gene.

References

YearCitations

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