CYTOCHROME P450 3A4 IS THE MAJOR ENZYME RESPONSIBLE FOR THE METABOLISM OF LAQUINIMOD, A NOVEL IMMUNOMODULATOR

References

Page 1

	Year	Citations
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura, Journal of Pharmacology and Experimental Therapeutics	1994	2.8K
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1 Raimund M. Peter, Ronald Boecker, Philippe Beaune, Chemical Research in Toxicology	1990	535
Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site Magang Shou, James Grogan, Julie Mancewicz, Biochemistry Aldo-keto ReductaseSignal RecognitionMolecular BiologySecondary MetaboliteRedox Biology	1994	349
Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9 Sandra Baldwin, J. C. Bloomer, Graeme Smith, Xenobiotica PharmacotherapyExperimental PharmacologyRespective Selective InhibitorsCyclosporine OxidasePharmaceutical Chemistry	1995	297
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene F. Peter Guengerich Chemical Research in Toxicology	1990	281
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS Chris H. Polman, Frederik Barkhof, Magnhild Sandberg‐Wollheim, Neurology	2005	228
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. Mary V. Relling, Toru Aoyama, Frank J. Gonzalez, Journal of Pharmacology and Experimental Therapeutics	1990	221
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline Kent L. Kunze, William Trager Chemical Research in Toxicology	1993	220
Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation Robin E. Pearce, Denise Greenway, Andrew Parkinson Archives of Biochemistry and Biophysics BiochemistryMedicineLiver PhysiologyInterindividual VariationHepatotoxicity	1992	189
In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase. T. Inaba, M Jurima, W. A. Mahon, Drug Metabolism and Disposition	1985	180

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