CYTOCHROME P450 3A4 IS THE MAJOR ENZYME RESPONSIBLE FOR THE METABOLISM OF LAQUINIMOD, A NOVEL IMMUNOMODULATOR

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Raimund M. Peter, Ronald Boecker, Philippe Beaune et al. · Chemical Research in Toxicology · 1990 · 535 citations

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

Magang Shou, James Grogan, Julie Mancewicz et al. · Biochemistry · 1994 · 349 citations

Aldo-keto Reductase, Signal Recognition, Molecular Biology +18

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

Sandra Baldwin, J. C. Bloomer, Graeme Smith et al. · Xenobiotica · 1995 · 297 citations

Pharmacotherapy, Experimental Pharmacology, Respective Selective Inhibitors +21

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

F. Peter Guengerich · Chemical Research in Toxicology · 1990 · 281 citations