Hedgehog Signaling Regulates Differentiation from Double-Negative to Double-Positive Thymocyte

Mutations affecting segment number and polarity in Drosophila

Christiane Nüsslein‐Volhard, Eric Wieschaus · Nature · 1980 · 4.4K citations

Population Genetics, Developmental Genetics, Genetics +6

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Mature B, Autoimmune Disease, Lymphocyte Development +4

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell · 1993 · 2.2K citations

Molecular Neuroscience, Developmental Biology, Signal Transduction +14

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

Andrea Vortkamp, Kaechoong Lee, Beate Lanske et al. · Science · 1996 · 2K citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Donna M. Stone, Mary Hynes, Mark Armanini et al. · Nature · 1996 · 1.1K citations

Knockout Mouse, Tumour-suppressor Gene, Signal Transduction +11