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In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance

Molecular PharmacologyMedicinal ChemistryPharmaceutical SciencePharmacokinetic ModelingBiochemistryMedicineDrug DiscoveryVitro–in Vivo ExtrapolationNatural SciencesPredicted ClearancePharmacotherapyPharmacologyPhysiologically-based Pharmacokinetic ModelingPharmacokineticsVitro Kinetic ParametersPharmacodynamic ModelingTranslational PharmacologyDrug Analysis