DCC constrains tumour progression via its dependence receptor activity

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

Eric R. Fearon, Kathleen R. Cho, Janice Nigro et al. · Science · 1990 · 1.7K citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

Amin Fazeli, Stephanie Dickinson, Michelle L. Hermiston et al. · Nature · 1997 · 768 citations

Knockout Mouse, Tumor Biology, Oncology +7

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

Kazuaki Takaku, Masanobu Oshima, Hiroyuki Miyoshi et al. · Cell · 1998 · 607 citations · Full text

Tumor Biology, Compound Mutant Mice, Intestinal Tumorigenesis +10

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

Riccardo Fodde, Winfried Edelmann, Kan Yang et al. · Proceedings of the National Academy of Sciences · 1994 · 526 citations · Full text

Large Bowel, Targeted Chain-termination Mutation, Gastroenterology +16

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

Patrick Mehlen, Shahrooz Rabizadeh, Scott J. Snipas et al. · Nature · 1998 · 414 citations · Full text