Concepedia

Stereocontrolled approaches to 9(0)-methanoprostacyclin

Akihiko Sugie, Hiromi Shimomura, Junki Katsube, H. YAMAMOTO

Tetrahedron Letters · 1979 · 12 citations · 2 references

Concepts

PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsMacrocycle SynthesisRetrosynthetic AnalysisStereochemical OptimizationMacrocyclic CompoundsRational Stereoisomer SelectionStereospecific Reaction Design

References

2

Total synthesis of carboprostacyclin, a stable and biologically active analogue of prostacyclin (PGI2)

K. C. Nicolaou, W. J. Sipio, Ronald L. Magolda et al. · Journal of the Chemical Society Chemical Communications · 1978 · 51 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

New synthetic routes to 9(0)-methanoprostacyclin. A highly stable and biologically potent analog of prostacyclin

Masakatsu Shibasaki, Junichi Ueda, Shiro Ikegami · Tetrahedron Letters · 1979 · 38 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11