Suppression of arthritic bone destruction by adenovirus‐mediated dominant‐negative Ras gene transfer to synoviocytes and osteoclasts

Abstract

Ras-mediated signaling pathways are involved in the activation of RA SFCs and the destruction of bone in arthritic joints, suggesting that inhibition of Ras signaling can be a novel approach for RA treatment that targets both synovial cell activation and bone destruction in the RA joint.