Chemistry Letters · 1980 · 27 citations · 8 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisRetrosynthetic AnalysisIsoquinoline AlkaloidsIsoquinoline ChemistryIsoquinoline SynthesisLactam SynthesisMedicinal Chemistry ApplicationsPlant AlkaloidsQuinoline AlkaloidsRegioselective Synthesis
Abstract Isoquinoline alkaloids, thalifoline, corypalline, and cherylline, were synthesised by application of the cyclisation reaction of β-phenylethyl isocyanate to N-methylisoquinoline lactam with Magic Methyl and the regioselective cleavage reaction of aromatic methoxyl groups with methionine and methanesulphonic acid.
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