The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

Cheng‐Ting Chien, Paul L. Bartel, Rolf Sternglanz, +1

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyReporter GeneGenomicsProtein Genetics +20

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

Gillian S. Ashcroft, Xiao Yang, Adam B. Glick, +8

Nature Cell Biology

InflammationCytokineImmunologyImmune RegulationChronic Inflammation +8

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

Carl Nathan

Journal of Clinical Investigation

Neutrophil ActivationImmunologyInnate ImmunityRedox BiologyCellular Physiology +21

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

G. Angus McQuibban, Jiang-Hong Gong, Eric M. Tam, +3

Science

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

Abderrazzaq Belaaouaj, Ronald McCarthy, Mary Baumann, +4

Nature Medicine

InflammationHost ResponseGranulocytePathogenesisImmunology +10

A sensitive new substrate for chymotrypsin

Eric G. Delmar, Corey Largman, James W. Brodrick, +1

Analytical Biochemistry

Protein FunctionBiochemistryNatural SciencesCellular BiochemistryCell Signaling +1

Impaired wound healing in mice with a disrupted plasminogen gene

John Rømer, Thomas H. Bugge, Charles Fyke, +4

Nature Medicine

InflammationImmunologyWound CarePlasminogen GeneVascular Biology +7

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

Carl Nathan, S Srimal, Claire Farber, +5

The Journal of Cell Biology

ImmunologyPathologyImmune SystemImmunotherapyInflammation +18

A novel genetic system to detect protein-protein interactions

Ching‐Ting Chien

Proc Natl Acad Sci USA

InteractomicsNatural SciencesComputational BiologyMolecular BiologyProtein Engineering +5

Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.

Richard Thompson, K. Ohlsson

Proceedings of the National Academy of Sciences

Protein SecretionPotent InhibitorImmunologyProteasomeHuman Parotid Secretions +14