Genotype-phenotype associations between chymase and angiotensin—converting enzyme gene polymorphisms in chronic systolic heart failure patients

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Brigitte Rigat, C. Hübert, F Alhenc‐Gelas et al. · Journal of Clinical Investigation · 1990 · 3.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

Klaus Lindpaintner, Marc A. Pfeffer, Reinhold Kreutz et al. · New England Journal of Medicine · 1995 · 910 citations · Full text

Life Sciences, Cardiology, Genetics +11

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

H Urata, Ayaka Kinoshita, K S Misono et al. · Journal of Biological Chemistry · 1990 · 880 citations · Full text

Life Sciences, Biochemistry, Cardiology +11

Angiotensin-Converting Enzyme in the Human Heart

A.H. Jan Danser, Maarten A.D.H. Schalekamp, Willem A. Bax et al. · Circulation · 1995 · 763 citations

Medicine, Cardiology, Genetics +11

Stimulation of Collagen Production by Transforming Growth Factor-β ₁ During Differentiation of Cardiac Fibroblasts to Myofibroblasts

Victor Petrov, Robert Fagard, Paul Lijnen · Hypertension · 2002 · 422 citations

Life Sciences, Cell Biology, Physiology +13