Inhibitory Action of Benzo[α]pyrene on Hepatic Lipoprotein Receptors In Vitro and on Liver Lipid Homeostasis in Mice

Abstract

B[α]P demonstrates inhibitory action on LSR and LDL-R, as well as ABCA1, which we propose leads to modified lipid status in B[α]P-treated mice, thus providing new insight into mechanisms underlying the involvement of pollutants in the disruption of lipid homeostasis, potentially contributing to dyslipidemia associated with obesity.