Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1).

Michael L. Dustin, K H Singer, D T Tuck et al. · The Journal of Experimental Medicine · 1988 · 678 citations · Full text

Life Sciences, Cell Biology, Immunology +15

Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice

Huanjie Yang, Di Chen, Qiuzhi Cindy Cui et al. · Cancer Research · 2006 · 585 citations

Medicine, Oncology, Pharmacology +13

Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation

Miguel P. Soares, Mark P. Seldon, Isabel Pombo Grégoire et al. · The Journal of Immunology · 2004 · 459 citations

Life Sciences, Cell Biology, Molecular Biology +15

Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

Jeong‐Hyung Lee, Jeong‐Hyung Lee, Tae Hyeon Koo et al. · Biochemical Pharmacology · 2006 · 309 citations

Life Sciences, Molecular Biology, Pharmacology +13

Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols

Catherine Andreadi, Lynne Howells, Paul Atherfold et al. · Molecular Pharmacology · 2005 · 211 citations

Life Sciences, Biochemistry, Pharmacology +17