Concepedia

The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP–PKA-dependent signaling pathway

Wei Zhu, Qianju Jia, Yun Wang, Yuhua Zhang, Min Xia

Free Radical Biology and Medicine · 2011 · 218 citations · 31 references

Concepts

Life SciencesBiochemistryPharmacologyCell SignalingMetabolic RegulationMetabolismGlutathione MetabolismHepatotoxicity MechanismsOxidative Stress In HepatotoxicityOxidative Stress PhysiologyReactive Oxygen SpeciesRedox SignalingAnthocyanin ChemistryAnthocyanin DerivativesFlavonoid Pathway RegulationGlutathione ProtectionReactive Oxygen Species GenerationReactive Oxygen Species HomeostasisReactive Oxygen Species Injury

References

31

Global Prevalence of Diabetes

Sarah H. Wild, Gojka Roglić, Anders Green et al. · Diabetes Care · 2004 · 15.3K citations

Public Health, Demography, Population Health Sciences +12

Biochemistry and molecular cell biology of diabetic complications

Michael Brownlee · Nature · 2001 · 9K citations

Life Sciences, Biochemistry, Cell Biology +14

Increased oxidative stress in obesity and its impact on metabolic syndrome

Shigetada Furukawa, Takuya Fujita, Michio Shimabukuro et al. · Journal of Clinical Investigation · 2004 · 5.3K citations · Full text

Life Sciences, Biochemistry, Pathobiology +17

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Hiroyuki Kanda · Journal of Clinical Investigation · 2006 · 2.6K citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Inflammation, stress, and diabetes

Kathryn E. Wellen · Journal of Clinical Investigation · 2005 · 1.2K citations

Life Sciences, Endocrinology, Immunology +17